Amanda Anisimova was born to Russian parents in New Jersey, USA. Her family later moved to Miami where better training opportunities were available. Her older sister Maria played college tennis at the University of Pennsylvania.
Anisimova is represented by talent agency IMG. IMG also represents Serena Williams and the retired Maria Sharapova.
Anisimova wears Nike apparel and shoes on the court. She currently wears the Nike Air Zoom Zero shoes.
Anisimova has a racquet deal with Babolat. She currently uses the Babolat Pure Drive racquet on the court.
In early 2020, Anisimova signed a global sponsorship deal with sports beverage maker Gatorade.
Therabody announced a multi-year partnership with Amanda Anisimova in 2020. Theragun improves muscle care for athletes through its handheld vibration therapy devices.